An attractive young Geneticist Scientist, Dr. Amanda Haze (Crystal Allen), develops a serum for regenerating cells that come with self-healing abilities and possible immortality. Her employer Murdoch (John Rhys-Davies), an evil minded financier, is ramrodding a group to find a fresh supply of blood orchids needed to experiment further with the regenerating nectar. The tail of an anaconda is cut off and almost immediately grows into two ferocious man-eating giant serpents with non-stop hunger. The woods of Romania are ripe for blood-lust.The CGI is pretty sloppy and goes hand in hand with the less than flawless story line and acting. Almost comical are scenes of the giant snakes flipping their prey into the air before swallowing whole.Don E. FauntLeRoy directs. Other players: Linden Ashby, Danny Midwinter, Claudia Bleont, Calin Stanciu and Ana Ularu.

Donald E. FauntLeRoy (David Wolper's North and South, Book IV) directs with his acclaimed stellar style and delivers a fine entry in the Anaconda saga. Acting as cinematographer as well, he creates a environment of overwhelming dread and stark raving fear as he uses Romanian locations to stunning effect. Working from a script that is both intelligent and exciting, FauntLeRoy coaxes superb performances from a renown cast of actors, some of whom are returning after their respective triumphs in the previous Anaconda film. With an inspiring score by Peter Meisner, pulse pounding and atmospheric, this is an incredibly intense motion picture experience. Not for the faint of heart, the thrills never let-up and some of the set piece sequences will likely sear fantastic imagery into collective psyche of any audience. Probably the best sequel to the original Anaconda, the film is certainly superior to most sequels and offers a cautionary environmental message that gives it a bit more gravitas. There are indeed rampaging anacondas featured but Anacoda: Trail of Blood rises above the average horror film with production values seldom seen in movies of this type. The special effects are breathtaking at times and the shocks are unrelentingly intense. Simply one of the best horror films produced in 2009.

They insist on making this trash don't they? One crappy snake movie after another and none of them make any sense. This 90 minute nightmare picks up where the previous Hasselhoff led nightmare left off. A scientist has been commissioned by a millionaire to develop a serum from the blood orchid to try and cure his bone cancer. While the scientist is out inspecting his orchids, a large anaconda in his lab suddenly breaks out of its enclosure, tracks him down and does what every homicidal CGI snake does best. After losing contact with his scientist, the millionaire, played by John Rhys Davies, believes that this guy may have received a better offer so rather than waste any time on common sense to at least check on him, he instead hires a hit-man to finish him off along with some other girl that he's been associated with. And that's pretty much the whole stupid story, such as it is. The serum has remarkable regenerative capabilities as even cutting the head off a snake won't kill it for long as after injecting the serum it will enable the snake to grow a new one. That sound you can hear is the pitiless laughter of every geneticist in the world.And just when you think that this non-story can't possibly get any worse, it suddenly does. I won't bore you with the finite details of what every single idiot ends up doing when in the presence of a large snake done in bad CGI, but I will say that if you wildly fire a machine gun from side-to-side when the snake is directly in front of you then quite frankly you deserve to die.I don't know why they continue wasting money in making crap like this and in every movie I've ever seen that has a larger than life snake in it, they just can't manage to make this thing look lifelike. If they can make animals that have been extinct for millions of years look lifelike, then it stands to reason that you can do that for a snake too right? Wrong obviously. Remember the large snake in the original Conan the Barbarian movie? That was more lifelike than this nonsense. You'd think that in almost 30 years it'd be perfected.This flick is just bad in every sense of the word. Despite the first anaconda movie being as pathetic as it is, it shines like a beacon when compared to this disaster. Anaconda 4 features lots of running, lots of bad driving, lots of arguing and an annoying number of people that just can't shoot straight. That is until you want to hit a fuel can embedded in a snakes mouth a 100 feet away, then after 2 shots you'll be dead on.I caught this on late night TV and I still feel ripped off. I'm still trying to work out how a giant snake can't manage to outrun a guy stumbling over uneven ground, but it's somehow fast enough to catch up to a speeding car travelling on a sealed road. If someone who actually wrote the screenplay for this can answer that then I'd appreciate it.

Forget that it's a franchise that extensively detours away from its original source material in theme, action and quality. Forget that. It's how amazingly stupid this screenplay is. It's really, really bad. A jumble of useless dialogue and cardboard characters dragged through a paper think plot idea.I did not see Anaconda 3 so perhaps I am missing large chucks of the story. Though I can't see how.Plot: (I kid you not!) Snake lady easily casually befriends young man, a stranger to her, while walking through the wood with two (we are told later) cops, who are easily killed at the next stop on the trail by a very poorly rendered large snake. Enter two couples in an SUV. Who are looking for base camp. We don't who they are. The snake exists only to kill people (not for food) just to kill them and the snake seems to literally go from one human being to the next. Lead pretty girl with new friend get chased by a group of assassins hired by John Rhys-Davies (What the F...?) in the first five minutes to kill a scientist who gyped him and his Gal Friday. The 'before mentioned' pretty lady. A log in the road stops the two couples in the black SUV, they decide to walk to Base Camp. The snake kills more. They showed it way too much. Pretty girl seems like she knows more than she's letting on. Down in some caves the young man/stranger (who behaves as though giant snakes, assassins and 'blood' flowers' are the norm) the pretty faced women encounter all kinds of trouble and should have been killed at least a half a dozen times. The SUV people find a corpse at bade camp and one of them gets a bad mosequeto bite. Pretty lady and stranger boy outrun a 90 foot snake meeting up with the SUV people and the assassins at an archeology dig. The snake kills some more people. Pretty Lady gets knocked out. Stranger boy leaves but drops his keys behind for some tension later. Evidently she got knocked out dropping two feet from the ground though she didn't her head. He doesn't hear his keys drop. People do really dumb things. Now there's a serum in all of this conveniently hiding when an SUV guy and pretty lady when the assassins have them prisoners. The snake kills some more people. Okay the SUV people have no purpose in the story -- they're fodder too. The assassins are seven strong and are only for the CGI snake. Some more people die. And Pretty lady planted those flowers to make up for all the bad she's done. (We assume from the last movie) Stranger boy meets up with SUV people and they know him. Surprise, he was looking for base camp all along too. Evidently the are archeologists on what appears to be a secret dig. They are so self important that you think they have something to do with the story but by this time there is no story left. Okay and now there's something about a serum and a diary with instructions on to make more serum, which they conveniently discover whenever they need to advance the story (what story?), one vial, a coffee can fill of vials and the diary and then more people get killed by the plastic snake. An SUV person sacrifice his life for pretty Lady even though he has only known her all of two hours. John Rhys-Davis appears again before getting his head bit off. And Pretty looks sad when she puts time bombs on a small flower bed in caves. There is an explosion and she escapes in an SUV with stranger boy but one last assassin tries to stop them and the movie ends.I kid you not! We were clueless. We stared at each other the other night while watching it on TV sci-fi channel -- shaking our heads because the narrative was nearly non-existent. Poorly written, badly directed.Crap on a stick.