This is a very cool live-action/animated movie starring Bill Murray as Frank Detorre, who after eating some bad food contracted a life-threatening virus. In the movie, the internal organs of Frank's body is an animated world known as the City of Frank, and is where a policeman white blood cell named Osmosis Jones (Chris Rock) and a cold pill Frank took named Drix (David Hyde Pierce) attempt to stop the virus known as Drax (Lawrence Fishburne) from claiming Frank's life.I thought this movie is very clever and imaginative, putting the human body into a whole new perspective. It makes your "insides" seem like an entire and adventurous different world, where in the film the white blood cells are law enforcement officers, lymph nodes are police stations, veins are highways, blood is water/lava, stomach is a bus station, a rowdy club is a pimple, and the germs and bacteria are the criminals.Marc Hyman wrote a fun, imaginative and adventurous script for the movie, cleverly depicting (in animation) how the human body fights infections and sickness. Brothers Bobby and Peter Farrelly did a fine job directing the film, making you suspend reality and imagining your body working like it is depicted in the film. Kudos to the team who did the animation work - bright, colorful and vibrant - nothing like some of those dull-looking and washed-out CGI animation you see nowadays. And, the live-acting and voice casting were great - realistic and believable.As this movie is raged PG, there is also quite a bit of bodily humor, puns and jokes, especially involving digestion, going to the restroom, passing gas, popping pimples from the face, food in the mouth.. (you get the drill). Therefore, you may not want to eat anything while watching this movie. But overall, it's a fun movie for both kids and adults - very entertaining! Grade B+

Osmosis Jones is one of Warner Bros. several animated films that failed at the box office. Some of those films were very good (The Iron Giant), others completely missed (Quest for Camelot). This one is sort of in the middle for my taste. Let me explain.I feel the animated portions are fantastic. The city of Frank is gorgeous to look at, and the characters are well developed. The story is also very engaging, energetic, and fast paced. For a few Kid Rock fans, he makes a cameo with his posse in one scene. These parts alone are worth the price of admission. Which brings me to my main criticism...The live action sequences are boring and uneven. I don't think the audience really cares about the live action scenes. They are obvious filler, they jut out like Excalibur in the stone. These scenes are only crucial at the beginning and towards the end of the movie.Overall, I liked the animated portions of the movie but could do without the live action.

This movie includes a bit of humor that I didn't care for, and a lot of other people probably won't either, but it's definitely worth getting over for the extremely original plot and plenty of other fun aspects.This is an unusual narrative that includes both animation and live action; it's not like in "Who Framed Roger Rabbit" or (shudder) "Cool World" where the animated characters mingle with live action ones, it jumps between worlds. The animated world takes place inside Frank Detorre's (Bill Murray's) body, where white blood cells behave like police officers and viruses behave like criminals, living in Frank's body as if it were a city. The City of Frank is run by an irresponsible mayor who has lead to a huge decline in the slovenly Frank's health. Frank ingests an extremely lethal virus named Thrax, and it's up to blacklisted cop Osmosis Jones and cold pill Drixenol to stop him before it's too late. Even in animated form, some of the humor is a little hard to stomach (no pun intended), though not as much as the live action parts. It's interesting that other movies that take place inside the human body like "Fantastic Voyage" or "Innerspace" are actually live action in their entirety, but are definitely less grotesque. The animation is done well, it's energetic and visually appealing. It's fun to see how exactly different sections of the body translate into the concept of it being a city, the zit, the nose, and the brain being the most imaginative areas.Thrax is a cool villain, and he actually kills quite a few characters in various gruesome and brutal ways on screen, which isn't something you'll usually see in a film primarily targeted at younger viewers. Osmosis Jones and Drix make for good protagonists, each having their own troubles they come to terms with. Their relationship is a bit stereotypical buddy cop movie style at times, but there's definitely some good stuff regarding Ozzie's past mistakes and Drix's fears of being ultimately useless.The live action side of things isn't as good as the animation, but it still has its moments. I'm a big fan of Bill Murray, and though he's still funny at times in this, it's definitely not his best work. The live action gross out humor is never outright disgusting, but things like the throbbing zit popping on a woman's lip are still pretty gross.Some unappreciated crude humor aside, I do recommend the film.

Good Animation, Nicely Voiced and With An Interesting Story, Osmosis Jones is a mediocre unique type of a animated movie which is good for time-pass and can entertain you with its mind-boggling but unique and satirical story about the human body along with nice Voice acting by Chris Rock(who was very good) and Lawrence Fishburne and decent effort from the directors Bobby and Peter Farrelly.The Story is quite unique about the body of Frank Detorre and what takes place in his body which is full of oily and harmful junk food which he consumes on a daily basis, and how the protective cells in the human body fight to destroy the bacteria and virus's which come into the body through the food. The Main Character is Osmosis Jones(Chris Rock), who is a cop cell who always manages to run into trouble and harm Frank's body and he tries to become famous by defeating the harmful virus which wants to kill Frank with his partner Thrax(Fishburne).The Voice acting by the lead actors are very good and they have successfully synchronised their voices with their characters and helped in making the characters look very real! Chris Rock and Laurence Fishburne have done a good job along with William Shatner. They Really put in their best efforts to make their respective characters look real and the characters they've voiced for are the most entertaining of the lot. The Others have also done a decent job in giving voice of these interesting cells and virus's.The Directors Bobby and Peter Farrelly have done an okay-ish job with their crew and have done and tried their best to make this movie very good, but it has its flaws, but you have to give them credit for doing their best. They did a good job with the voicing of the characters and helping the actors blend in with their characters and have made this movie a good one for time-pass.The Story of this movie is quite unique and its a good satirical dig at what happens inside the human body and they have tried to show the importance of these protective cells in destroying the virus's and helping us keep healthy and from getting diseases. The Writer Marc Hyman has done a great job in making this uniquely good script and because of the story this movie is quite worth the watch and worth your time.The Animation team has done a great job in showing all these protective cells and them destroying the virus's and how they ''live'' inside the human body and the animation is spot on in this movie and the animation team has really done their best in giving the audience a good time with this entertaining animation and these interesting characters.Well, if your quite bored and have nothing to do, you can try and watch this movie for time-pass and you will find it quite decent with its interesting story and colourful characters, but if your looking for a serious movie, pass this.My Rating: 6.3/10