I had to watch this in school in 8th grade science. Overall, this movie is ok I guess. Everything that is live-action is disgusting and terrible. The animation parts are entertaining and clever. I wouldn't recommend this movie, but its not terrible. There isn't much to say about this movie other than that really.

This would have been a great animated movie. However when they added the human characters it was awful.1. The animation was great. The cells moved like they were supposed to move. The world it painted looked interesting and pretty unique.2. The characters that are animated are great but the live action ones are terrible. Ozzy is funny, Drix is smart but has his own comedic side and the villains Thrax is great! Too bad that the humans are dull, gross and unintelligent morons that couldn't tie their own shoes. The daughter is smarter than her father and even then she's still bad at acting.3. The comedy is well done. I liked Ozzy and Drix with their funny banter. The other side characters are also very funny. Too bad that the human comedy is gross out humor that only a four year old could laugh at.4. The story is pretty nice. Thrax the virus tries to kill Frank in 48 hours so he can beat his record at killing humans. Ozzy and his new pal Drix are the only ones who can stop Thrax and have to work together. It's clique yes but it works. The humans...aren't very important with the story and are there just because.Like I've stated before it's the humans that ruined the movie. It's good but cut out the humans and this would be way better!

This is one of those rare gems that gets better and better with each viewing. There are so many in-jokes and subtleties packed into it, that it is impossible to get them all with just one viewing. Each repeat viewing evokes a new and unexpected chuckle or grin. Best viewed on DVD so you can pause and review what you just thought you saw. (Does that sentence make sense?) Although the Live Action parts are rough around the edges. Bill Murray is genius, as always, and the animation scenes are obviously a work of love. The one drawback is Chris Elliot, who, no matter what project he is in, brings the whole production to a crashing bore, due to his complete unlike-ability as an actor and a person.Those who "get" this film "get it", those who don't, chances are - never will.

This movie includes a bit of humor that I didn't care for, and a lot of other people probably won't either, but it's definitely worth getting over for the extremely original plot and plenty of other fun aspects.This is an unusual narrative that includes both animation and live action; it's not like in "Who Framed Roger Rabbit" or (shudder) "Cool World" where the animated characters mingle with live action ones, it jumps between worlds. The animated world takes place inside Frank Detorre's (Bill Murray's) body, where white blood cells behave like police officers and viruses behave like criminals, living in Frank's body as if it were a city. The City of Frank is run by an irresponsible mayor who has lead to a huge decline in the slovenly Frank's health. Frank ingests an extremely lethal virus named Thrax, and it's up to blacklisted cop Osmosis Jones and cold pill Drixenol to stop him before it's too late. Even in animated form, some of the humor is a little hard to stomach (no pun intended), though not as much as the live action parts. It's interesting that other movies that take place inside the human body like "Fantastic Voyage" or "Innerspace" are actually live action in their entirety, but are definitely less grotesque. The animation is done well, it's energetic and visually appealing. It's fun to see how exactly different sections of the body translate into the concept of it being a city, the zit, the nose, and the brain being the most imaginative areas.Thrax is a cool villain, and he actually kills quite a few characters in various gruesome and brutal ways on screen, which isn't something you'll usually see in a film primarily targeted at younger viewers. Osmosis Jones and Drix make for good protagonists, each having their own troubles they come to terms with. Their relationship is a bit stereotypical buddy cop movie style at times, but there's definitely some good stuff regarding Ozzie's past mistakes and Drix's fears of being ultimately useless.The live action side of things isn't as good as the animation, but it still has its moments. I'm a big fan of Bill Murray, and though he's still funny at times in this, it's definitely not his best work. The live action gross out humor is never outright disgusting, but things like the throbbing zit popping on a woman's lip are still pretty gross.Some unappreciated crude humor aside, I do recommend the film.