Clients for a certain lawyer are bumped off by a maniacal physician who leaves his calling card by "Rx" along with each individual victim's number as he kills them via poison. Dr. Crispin hopes a well-renowned detective, John Church, will halt his plans of retirement and seek the identity of the killer before he winds up as the next victim(not to mention, rescue his law practice which took a hit thanks to the fact that if you attain Dudley as your lawyer you wind up dead).Patric Knowles, as Private Eye Jerry Church, many will know from FRANKENSTEIN MEETS THE WOLF MAN, is the star while Anne Gwynne(HOUSE OF FRANKENSTEIN)is his worried newspaper reporter wife, Kit Logan. With Samuel Hinds(THE RAVEN)as attorney Dudley Crispin, Paul Cavanagh(THE SCARLET CLAW)his brother John, bug-eyed Mantan Moreland as Church's oft-abused butler Horatio(sure to make African-Americans cringe as honkies push and slap him around as the poor guy is used as a bumbling foil), and Shemp Howard(of all people)as a goofy cop. Edmund MacDonald is a cop who wants Church to partner with him on the case of the mysterious psychopath, Dr. Rx. Marital shenanigans between Knowles and Gwynne are used as comic touches as is the casting of Moreland and Shemp to off-set the morbid plot of a killer who keeps to taking out low-life criminals in the mobster underworld. The signature of Rx could be the key to the murderer's undoing. Lionel Atwill, in coke-bottle glasses, is the character of suspicion(which means he's likely a red herring), but his part is so small he's almost a non-entity. I was disappointed in this one more because it plays too much for laughs and not chills. The only real "horror" to the movie is the gorilla scene where it appears that Church will be another victim on Rx's hit list.

Private Detective Jerry Church (Patric Knowles) is asked to investigate the strange deaths of several recently acquitted men. The only clue is the mysterious calling card found on the body of each victim of a man known only as "Doctor Rx". Soon after taking the case, Church is on hand to see a man named Zarini acquitted, only to fall dead before he can leave the courtroom. To solve the series of murders, Church is kidnapped, his wife's life is threatened, and he is strapped to a table by Doctor Rx and prepped for an operation involving organ transplantation with a gorilla. Will Church survive this ordeal and unmask the killer? As far as the classic Universal horror (and horror is used very loosely here) films of the 30s and 40s go, The Strange Case of Doctor Rx is about as bad as you'll run across. I place it at the bottom of the heap with the unfortunate She-Wolf of London. I described The Strange Case of Doctor Rx to a friend as a Charlie Chan movie without any of the charm or interest of a Charlie Chan movie. Knowles' Church doesn't make for a very effective or interesting lead. He's just too bland. Lionel Atwill is billed second, but he has so little screen-time you'll forget he's even in the film. And when Atwill is on screen, he's reduced to playing the role of the most embarrassing red herring I've ever run across. Gwynne is okay as the love interest / wife, but she can't save the film on her on. The highlights of the cast are Shemp Howard and, especially, Mantan Moreland. They have a scene together involving shooting dice that's laugh-out-loud funny. Moreland, as usual, steals most every scene in which he appears. Other weaknesses: the films plotting is plodding, the direction is pedestrian, the mystery isn't very mysterious, and the horror is pretty much missing altogether. As most everyone who has written about The Strange Case of Doctor Rx has pointed out, the one scene of real horror feels like it was cut from another film. Other than Moreland, the one bright spot worth mentioning is the "look" of the film. Like most other Universal pictures from this period, the movie looks like a million bucks. Overall, a very disappointing affair that I'll be generous to and give it a 4/10.

A killer is going around murdering men who have eluded the clutches of the law thanks to the legal system, known only as Doctor Rx. The police ask private detective Jerry Church to help them, but he insists on returning to a legal practice in Boston. When DA Crispin asks for Church's help, he say he'll go watch the end of his latest case (involving gangster Tony Zarini) as a favor, but when Zarini mysteriously becomes Rx's 6th victim Church says he'll work on the case. This all changes when Church meets up with former flame, mystery writer Kit Logan, and after they marry Church now wants a peaceful life and decides to drop the case again, but after he is threatened by suspect Ernie Paul, he gets even worse treatment from Dr. Rx himself who plans to transplant Church's brain into the head of a gorilla. Is there no stopping this fiend? The film doesn't exactly stay in one genre with mystery, crime, comedy (thanks to Mantan Moreland & Shemp Howard), and romance, but you can't say the film isn't fun. After the midway mark of the film, it seems to get more interesting and curious to know what's going on here and when Dr. Rx actually appears, boy the film jumps up in fun. The cast is full of the usual Universal stock company of actors and they play their roles to the best they can. Fun film all together, Rating, 7.

(possible spoilers) If you're looking for a lot of Lionel Atwill, you will be disappointed as he only has a few scenes playing the most obviously named red-herring in film history, Dr. Fish. However, if you're looking for a good little suspenser, this is a solid b-movie from Universal. The cast is generally good, only Patrick Knowles comes off as too brash and pompous as the hero. It's hard to root for him as his charm is very thin and his arrogance fat. It is nicely paced and directed. The best part about the film is Dr. Rx himself - a madman vigilante killer with an evilly raspy voice and a gorilla for a sidekick. It's a fun time-passer and one of the better horror/mysteries from Universal.