Re-formed by a coded message to their web site, a group of animal rights activists set off to free an imprisoned colleague from a terrifying ordeal. Their rescue mission leads them to a disused lab, but what should have been a simple raid turns into a series of twisted and mind bending incidents where the free and the caged switch places, in this tormented psychological horror. LD 50 Lethal Dose is a 2003 Horror film that tries harder than it should and it's packed with some terrible perfomances (including Tom Hardy) and a set of twists and gore that it copy paste from other classic horror movies. Overall a horrible horror flick with horrible characters and perfomances. (0/10)

Dude this movie was HILARIOUS!!! its about this dude, and he couldn't find his car.Sorry wrong movie but same intellectual level. Like the teen comedy "Dude, Where's My Car", "LD 50 Lethal Dose" bravely seeks the lowest rung of its genre's (in this case sci-fi, sort of) intelligence ladder. The only positive outcome is the possibility that first-time writer Matthew McGuchan is now ashamed enough about his sad screenplay to seek a permanent career in the food service industry.Basically "LD 50 Lethal Dose" is what you would have if someone tried to remake 1970's "The Andromeda Strain" under a lot of budget constraints. Speaking of budgets, can anyone find the $8 Million allocated to this movie? Very little of even that modest amount makes it to the screen. And speaking of mysteries, how did they manage to find that kind of financing for this turkey?"LD 50 Lethal Dose" has the same production design concept as the two "Saw" movies and "The Hole"; find an abandoned industrial building, go inside, and roll camera. But even though this particular claustrophobic set has more potential than the others, the finished product is not even remotely in their league. A few artsy interior shots can't salvage a premise this lame or a script this staggeringly bad.If you enjoy life on the bottom rung of the sci-fi ladder you would be better served by something that at least has some innate charm (insert "Godzilla" here). "LD 50 Lethal Dose" might have eventual parody potential but I am not masochistic enough to watch it again for confirmation.Then again, what do I know? I'm only a child.

Some raw powerful performances, and truly chilling moments in this haunting Simon De Selva movie. The story takes that classic horror/science fiction set-up - a disparate and desperate bunch of characters entering some hostile environment and being menaced by a mysterious predator (From "Alien" to "Scooby Do"!) - and gives it a smartly original slant (the energy of the human soul being channelled into some new form of WMD). De Selva's direction is slick, atmospheric; and brings us some great set-piece moments, and nightmarish images. Tom Hardy (as Matt) brilliantly charts his character's journey from zero to hero, and Leo Bill plays the self-serving Danny with great intensity and truth. Most of the movie is set in a perfectly designed, creepily claustrophobic tunnel system where experiments are conducted on human "lab rats". And it's all carried along by a heart-thumping soundtrack.

"Lethal Dose 50" is a stylish British production that deserves a view. It's a for sure a great and pleasure full time killer. The cast isn't that well known, although maybe the spice girl " Melania Brown" could be a recognizable face. The director of this horror SF flick, "Simon De Selva" sets a pretty impressive movie onto your screen as first time director! The tension is superb and of a perfect level. The director knew how to put in the suspense moments at just the right and perfect time. Acting is of a decent quality though can't be called amazing but actually I think that was for sure not needed into this flick. Everyone played their part to best of their ability and in which they succeeded for sure. Sometimes I did spot some "28 Days Later" links into the film but it never annoyed me in anyway. It didn't interfere into this flick in a negative way. The music is good and adds by times that certain needed drive to get some scenes, even the whole movie into a certain gear so it starts rolling onto your screen and creates that great feeling of being locked onto your screen. Which also gives that extra power onto these "jump chair" scenes. Where into this movie one is to be found for sure!Not as great as "28 Days Later" but for sure much better as "Dogsoldiers"! A' kinda must see if you're in for a foreign filled film evening.Dario/ 7.5 outa 10.