Eugene (Ray Liotta) and Dominick 'Nicky' Luciano (Tom Hulce) are twins living in Pittsburgh together. Eugene is studying to be a doctor and finds out that he got into Stanford. Nicky is mentally slow and working as a trash man paying for Eugene's school. Eugene is leery of Nicky's crass work partner Larry Higgins. Nicky wants to live with Eugene in a house by the lake but Eugene is wondering if Nicky could live by himself. Eugene starts a relationship with nurse Jennifer Reston (Jamie Lee Curtis).These are two good performances especially Tom Hulce. The brothers' chemistry is great. There is real dramatic complexity with their relationship. Everybody is great including Curtis. It's a good sentimental melodramatic movie. It would be nice to make Mikey more of a constant sidekick to Nicky and a more central part of the movie from the start.

Mentally impaired Dominick (Tom Hulce, Oscar-winner for Amadeus) is putting his intern brother, Eugene (Ray Liotta at his best), through medical school by collecting garbage. Eugene is torn between his nascent career and his responsibility for his brother. Todd Graff as Nicky's partner on the garbage truck, Larry, brings humor and sympathy to what could have been a throw-away role. I collected garbage for two Summers in my Hometown, and the scenes of Nicky and Larry chatting with the folks on their route are completely authentic. Powerful and exhilarating, with Jamie Lee Curtis as the sympathetic student who inadvertently comes between the brothers."...and you have to believe in your strength, Nicky"

Of all movies I have seen, I have to say that Dominick and Eugene is the best drama movie I have ever seen. It had a good plot and I found I related well with Dominick. Tom Hulce was a great character and Ray Liotta was, too. I did have a bit of a problem with the way Dominick was treated, but then, nobody is perfect. Dominick and Eugene is a very entertaining movie and I wouldn't mind seeing it again.

I just purchased and viewed the DVD of this film. The DVD transfer is from last year, 2001. This 1988 film is really a great little film. Overlooked by most people. I saw it in the theater in 1988 and have loved it ever since. I love the opening shot of Pittsburgh (not Baltimore, as another user commented). Makes Pittsburgh look like one of the most beautiful cities in the world! And I must say, the tour of Pitts on the garbage truck with Nicky is a very scenic, interesting one! Tom Hulce, as everyone else has said, gives a remarkable, wonderful performance. The DVD is a good transfer, with no extras, but a widescreen format. I recommend it to those who love the movie.